BIO422 Mechanism of Signal Transd

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Course Code Course Title Weekly Hours* ECTS Weekly Class Schedule
TUE 13-15:00h THU 11-12:00h
Prerequisite It is a prerequisite to


Lecturer Office Hours / Room / Phone

Currently not available

Assistant Muhamed Adilovic Assistant E-mail
Course Objectives The main goal of this course is to provide students with basic principles of intracellular signalling networks, and train them for technical approaches in analysis of key signalling regulatory pathways, cell cycle control mechanisms and biology of cancer occurrence.
Textbook Lodish, Berk, Kaiser, Krieger, Scott, Bretscher. Ploegh and Darnell. (2008) Molecular Cell Biology, 6th Edition by W. H. Freeman and Company, New York, USA
Additional Literature
Learning Outcomes After successful  completion of the course, the student will be able to:
  1. Recognize main signal transduction pathways and explain their biological outcome.
  2. Demonstrate principles of protein / vesicular trafficking and control.
  3. Discuss cell cycle control mechanisms and cancer occurrence
  4. Examine and extract data from research publications
  5. Perform basic laboratory techniques to visualize and analyze molecules in intracellular networks
Teaching Methods
Teaching Method Delivery Teaching Method Delivery Notes
Week 1 Presentation of the Syllabus - Introduction of the Course
Week 2 Levels of Organization: Presentation of the Syllabus Organelles of the Eukaryotic cell Ch.1
Week 3 Visualizing, Fractionating and Culturing Cells ; Light microscopy, Electron microscopy, Purification of Organelles, Isolation and culturing the cells Ch.4
Week 4 Biomembrane structure: Lipid composition, structural organization, protein components Ch.5; Ch.6
Week 5 Moving proteins into Membranes and Organelles , QUIZ1 Ch.10
Week 6 Molecular mechanisms of vesicular trafficking and endocytosis Ch.12
Week 7 Signal transduction and cellular responses: Cell surface receptors and components of intracellular signal transduction pathways Ch.17
Week 8 G protein-coupled receptors, cAMP and PKA,second messangers MIDTERM EXAM Ch.17
Week 9 Receptor tyrosine kinases, Ras/MAP pathway, PI3/Akt pathway Ch.18
Week 10 Regulating the Eukaryotic Cell Cycle: CDKs and cell-cycle control Ch.19
Week 11 Regulating the Eukaryotic Cell Cycle: Checkpoints in Cell cycle regulation Ch.20
Week 12 Cell Birth, Lineage and Death: Stem cells and differentiation, QUIZ2 Ch.22
Week 13 Cell Birth, Lineage and Death: Cell Death and its regulation Ch.23
Week 14 Cancer: Tumor cells and Genetic basis of cancer , J.Club quiz Ch.25
Week 15 COURSE Overview , Laboratory assessment
Assessment Methods and Criteria Evaluation Tool Quantity Weight Alignment with LOs
Final Exam 1 40 1,2,3
Semester Evaluation Compenents
Laboratory 1 10 5
Mid term exam 1 30 1,2
Quizzes 2 10 1,2,3
Journal Club 1 10 4
***     ECTS Credit Calculation     ***
 Activity Hours Weeks Student Workload Hours Activity Hours Weeks Student Workload Hours
Lecture Hours 3 14 42 Assignments 3 6 18
Laboratory 2 6 12 Home Study 2 14 28
Midterm Exam Study 15 1 15 Final Exam Study 20 1 20
Quizzes 10 2 20
        Total Workload Hours =
*T= Teaching, P= Practice ECTS Credit =
Course Academic Quality Assurance: Semester Student Survey Last Update Date: 06/11/2020
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