Serum Levels of Interleukin-2 and Interleukin-2 Soluble Receptor in Patients with Vitiligo

TitleSerum Levels of Interleukin-2 and Interleukin-2 Soluble Receptor in Patients with Vitiligo
Publication TypeJournal Article
Year of Publication2016
Date Published02/2016
JournalBritish Journal of Medicine and Medical Research
Type of ArticleOriginal Research
Publication Languageeng
AuthorsKasumagic-Halilovic, E, Ovcina-Kurtovic, N, Soskic, S, Helppikangas, H, Ridic, O

Background: Vitiligo is a common skin disorder characterized by macular depigmentation of theskin. Although the etiopathogenesis of the disease is still unclear, several studies have shown thatwithin the cascade of pathogenesis of vitiligo, cytokines play an important role.Objectives: The aim of our study was to evaluate serum concentrations of interleukin- IL-2 (IL-2)and interleukin-2 soluble receptor (IL-2 sR) in patients with vitiligo and healthy subjects and also toasses a possible association between these cytokines and duration of the disease.Study Design: Case control study.Place of the Study: The study was carried out in University Clinical Center Sarajevo, Departmentof Dermatology and Venereology.Patients and Methods: Twenty one patients (11 female and 10 male; age range 15-53 years) withvitiligo and 20 healthy controls (10 female and 10 male; age range 17-52) were enrolled in thestudy. c The duration of vitiligo ranged from 2 to 252 months. Ten patients (47.62%) hadgeneralized, and eleven patients (52.38%) had localized vitiligo Serum concentrations of cytokines were measured using enzyme-linked immunoassay techniques.Results: Both IL-2 (median 22.600 pg/ml, range 20.900-76.100) and IL-2sR (median 76.100 pg/ml,range 15.700-183.800) in the patient group were significantly higher when compared with that of thenormal controls. When the serum cytokine level in vitiligo group were compared to total diseaseduration (Spearman correlation ρ), serum IL-2 was negatively (ρ= -0.000573, P= 0.9980) and IL-2sR was positively (ρ=0.241, P= 0.2797) correlated with total disease duration, but it is of borderlinesignificance.Conclusions: Our results showed hight serum levels of IL-2 and IL2 sR among vitiligo patientswhich may highligth a functional role of these cytokines in the pathogenesis of this disease.Keywords: Vitiligo; serum cytokines; interleukin-2; soluble interleukin-2 receptor.