Title | Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Date Published | 2015 Aug |
Journal | Med Glas (Zenica) |
Volume | 12 |
Issue | 2 |
Pagination | 113-21 |
Publication Language | eng |
Authors | Bego, T, Dujić, T, Mlinar, B, Semiz, S, Malenica, M, Prnjavorac, B, Ostanek, B, Marc, J, Čaušević-Ramoševac, A, Čaušević, A |
ISSN Number | 1840-2445 |
Keywords | Adult, Body Mass Index, Bosnia and Herzegovina, Hemoglobin A, Glycosylated, Humans, Metabolic Syndrome X, Middle Aged, Phosphatidate Phosphatase, Polymorphism, Genetic |
Abstract | AIM: To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.METHODS: This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real time PCR method.RESULTS: In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.CONCLUSION: Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS. |
DOI | 10.17392/795-15 |
Alternate Journal | Med Glas (Zenica) |