BIO422 Mechanism of Signal Transd
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| Course Code | Course Title | Weekly Hours* | ECTS | Weekly Class Schedule | ||||||
| T | P | |||||||||
| BIO422 | Mechanism of Signal Transd | 3 | 2 | 6 | TUE 13-15:00h THU 11-12:00h | |||||
| Prerequisite | BIO301 | It is a prerequisite to | None |
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| Lecturer | Office Hours / Room / Phone | Currently not available |
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| Assistant | Muhamed Adilovic | Assistant E-mail | madilovic@student.ius.edu.ba | |||||||
| Course Objectives | The main goal of this course is to provide students with basic principles of intracellular signalling networks, and train them for technical approaches in analysis of key signalling regulatory pathways, cell cycle control mechanisms and biology of cancer occurrence. |
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| Textbook | Lodish, Berk, Kaiser, Krieger, Scott, Bretscher. Ploegh and Darnell. (2008) Molecular Cell Biology, 6th Edition by W. H. Freeman and Company, New York, USA | |||||||||
| Additional Literature | ||||||||||
| Learning Outcomes | After successful completion of the course, the student will be able to: | |||||||||
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| Teaching Methods | ||||||||||
| Teaching Method Delivery | Teaching Method Delivery Notes | |||||||||
| WEEK | TOPIC | REFERENCE | ||||||||
| Week 1 | Presentation of the Syllabus - Introduction of the Course | |||||||||
| Week 2 | Levels of Organization: Presentation of the Syllabus Organelles of the Eukaryotic cell | Ch.1 | ||||||||
| Week 3 | Visualizing, Fractionating and Culturing Cells ; Light microscopy, Electron microscopy, Purification of Organelles, Isolation and culturing the cells | Ch.4 | ||||||||
| Week 4 | Biomembrane structure: Lipid composition, structural organization, protein components | Ch.5; Ch.6 | ||||||||
| Week 5 | Moving proteins into Membranes and Organelles , QUIZ1 | Ch.10 | ||||||||
| Week 6 | Molecular mechanisms of vesicular trafficking and endocytosis | Ch.12 | ||||||||
| Week 7 | Signal transduction and cellular responses: Cell surface receptors and components of intracellular signal transduction pathways | Ch.17 | ||||||||
| Week 8 | G protein-coupled receptors, cAMP and PKA,second messangers MIDTERM EXAM | Ch.17 | ||||||||
| Week 9 | Receptor tyrosine kinases, Ras/MAP pathway, PI3/Akt pathway | Ch.18 | ||||||||
| Week 10 | Regulating the Eukaryotic Cell Cycle: CDKs and cell-cycle control | Ch.19 | ||||||||
| Week 11 | Regulating the Eukaryotic Cell Cycle: Checkpoints in Cell cycle regulation | Ch.20 | ||||||||
| Week 12 | Cell Birth, Lineage and Death: Stem cells and differentiation, QUIZ2 | Ch.22 | ||||||||
| Week 13 | Cell Birth, Lineage and Death: Cell Death and its regulation | Ch.23 | ||||||||
| Week 14 | Cancer: Tumor cells and Genetic basis of cancer , J.Club quiz | Ch.25 | ||||||||
| Week 15 | COURSE Overview , Laboratory assessment | |||||||||
| Assessment Methods and Criteria | Evaluation Tool | Quantity | Weight | Alignment with LOs |
| Final Exam | 1 | 40 | 1,2,3 | |
| Semester Evaluation Components | ||||
| Laboratory | 1 | 10 | 5 | |
| Mid term exam | 1 | 30 | 1,2 | |
| Quizzes | 2 | 10 | 1,2,3 | |
| Journal Club | 1 | 10 | 4 | |
| *** ECTS Credit Calculation *** | ||||
| Activity | Hours | Weeks | Student Workload Hours | Activity | Hours | Weeks | Student Workload Hours | |||
| Lecture Hours | 3 | 14 | 42 | Assignments | 3 | 6 | 18 | |||
| Laboratory | 2 | 6 | 12 | Home Study | 2 | 14 | 28 | |||
| Midterm Exam Study | 15 | 1 | 15 | Final Exam Study | 20 | 1 | 20 | |||
| Quizzes | 10 | 2 | 20 | |||||||
| Total Workload Hours = | 155 | |||||||||
| *T= Teaching, P= Practice | ECTS Credit = | 6 | ||||||||
| Course Academic Quality Assurance: Semester Student Survey | Last Update Date: 06/11/2020 | |||||||||